Cytochrome P-450 CYP2D6

A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.

Also Known As:

CYP2D6; Cytochrome P450 2D6; CYP 2D6; Debrisoquine 4-Monooxygenase; Imipramine 2-Hydroxylase; Sparteine Monooxygenase; 2-Hydroxylase, Imipramine; 4-Hydroxylase, Debrisoquine; 4-Monooxygenase, Debrisoquine; CYP2D6, Cytochrome P-450; Cytochrome P 450 CYP2D6; Debrisoquine 4 Hydroxylase; Debrisoquine 4 Monooxygenase; Hydroxylase, Debrisoquine; Imipramine 2 Hydroxylase; Monooxygenase, Sparteine; P-450 CYP2D6, Cytochrome; P450 2D6, Cytochrome; Debrisoquine 4-Hydroxylase; Debrisoquine Hydroxylase

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - Oxygenases: 336
      - Mixed Function Oxygenases: 2207
        Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 2: 33
        Cytochrome P-450 CYP2D6: 1566
        Aryl Hydrocarbon Hydroxylases: 18
        Cytochrome P-450 CYP2D6: 1566
- Cytochromes: 2210
  - Cytochrome P-450 Enzyme System: 5452
    - Cytochrome P450 Family 2: 33
      - Cytochrome P-450 CYP2D6: 1566
    - Aryl Hydrocarbon Hydroxylases: 18
      - Cytochrome P-450 CYP2D6: 1566
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Hemeproteins: 196
    - Cytochromes: 2210
      - Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 2: 33
        Cytochrome P-450 CYP2D6: 1566
        Aryl Hydrocarbon Hydroxylases: 18
        Cytochrome P-450 CYP2D6: 1566

Smirnov Selected Research

Smirnov Research Topics

Disease

Drug/Important Bio-Agent (IBA)